My new favorite strip is a beautifully illustrated and wickedly satirical strip called The Perry Bible Fellowship. Nicholas Gurewitch first published the PBF in Syracuse University's Daily Orange in 2003 and has since appeared in the The Portland Mercury, The Rochester Insider, The Birmingham Black and White, and The New York Press. Basically, an indie grass roots strip that doesn't get much love elsewhere but should.
The Kids Are Thirsty
One More Day
No One is Thirsty
Similarly dark (well actually a lot darker) is the Square Lake. Once again, some of the sharpest and wittiest humor to grace newsprint never saw more than a four paper circulation. All that I can gather is that Square Lake originated and ran in the University of Illinois campus and perished shortly after about 3 years from 2000 - 2001. Having enjoyed a similarly underappreciated strip "Jim" while in college, I instantly felt a strong connection with this little strip. Enjoy.